The Effects of Diet, Overfeeding and Moderate Dietary Restriction on Sprague-Dawley Rat Survival, Disease and Toxicology

Author:

Keenan Kevin P.1,Ballam Gordon C.2,Dixit Rakesh1,Soper Keith A.1,Laroque Philippe1,Mattson Britta A.1,Adams Stephen P.1,Coleman John B.1

Affiliation:

1. Department of Safety Assessment and Biometrics, Merck Research Laboratories, West Point, PA 19486and Riom, France

2. Department of Safety Assessment and Biometrics, Purina Mills Inc., St. Louis, MO 63166

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference43 articles.

1. Effect of caloric restriction on oxidative stress biomarkers in liver and kidney of Sprague-Dawley rats;Adams;Fund. Appl. Toxicol.,1996

2. Tissue levels of 8-hydroxydeoxyguanosine (8-OHdG) in Sprague-Dawley rats fed ad libitum or fed a calorie-restricted diet;Adams;Fund. Appl. Toxicol.,1995

3. Caloric intake, body weight, and cancer: a review;Albanes;Nutr. Cancer,1987

4. Effects of moderate dietary restriction (MDR) on toxicity and toxicokinetic (TK) profiles of non-genotoxic pharmaceuticals in rats;Dixit;Fund. Appl. Toxicol.,1995

5. Modulation of carcinogenesis bioassay dose selection by moderate dietary restriction (MDR) in rats: relationship with cytochrome P450 (CYP) levels, enzyme activities and toxicokinetics (TK);Dixit;Fund. Appl. Toxicol.,1996

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