Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology-Reference-Cited by-同舟云学术

Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology

Published:2019-11-13 Issue:1 Volume:75 Page:77-86
ISSN:1079-5006
Container-title:The Journals of Gerontology: Series A
language:en
Short-container-title:

Author:

Newman Anne B¹²,Kritchevsky Stephen B³^ORCID,Guralnik Jack M⁴,Cummings Steven R⁵,Salive Marcel⁶,Kuchel George A⁷,Schrack Jennifer⁸,Morris Martha Clare⁹,Weir David¹⁰,Baccarelli Andrea¹¹,Murabito Joanne M¹²,Ben-Shlomo Yoav¹³¹⁴,Espeland Mark A¹⁵,Kirkland James¹⁶,Melzer David¹⁷¹⁸,Ferrucci Luigi¹⁹^ORCID

Affiliation:

1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania

2. Department of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pennsylvania

3. Sticht Center for Health Aging and Alzheimer’s Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina

4. Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland

5. San Francisco Coordinating Center, California Pacific Medical Center Research Institute San Fransisco, California, Bethesda, Maryland

6. National Institute on Aging, National Institutes of Health, Bethesda, Maryland

7. University of Connecticut Center on Aging, University of Connecticut Health, Farmington, CT, Baltimore, Maryland

8. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

9. Department of Internal Medicine, Rush Medical College, Rush University, Chicago, Illinois

10. Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, New York, New York

11. Department of Environmental Health Sciences, Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, New York

12. Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts

13. Population Health Sciences, University of Bristol, Bristol, UK

14. National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West), University Hospitals Bristol NHS Foundation Trust, Bristol, UK

15. Department of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina

16. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota

17. College of Medicine and Health, University of Exeter, Exeter, UK

18. Center on Aging, School of Medicine, University of Connecticut, Farmington, Connecticut

19. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

Abstract

Abstract Background Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods Summary of workshop proceedings from the 2018–2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.

Funder

National Institute on Aging

National Institutes of Health

Wake Forest Alzheimer’s Disease Core Center

Translational Geroscience Network

Robert and Arlene Kogod, the Connor Group

Ted Nash Long Life and Noaber Foundations

United Kingdom Medical Research Council

Wake Forest Older Americans Independence Center

Publisher

Oxford University Press (OUP)

Subject