A novel common variant in DCST2 is associated with length in early life and height in adulthood

Author:

van der Valk Ralf J.P.123,Kreiner-Møller Eskil4,Kooijman Marjolein N.123,Guxens Mònica567,Stergiakouli Evangelia8,Sääf Annika9,Bradfield Jonathan P.10,Geller Frank11,Hayes M. Geoffrey1213,Cousminer Diana L.14,Körner Antje15,Thiering Elisabeth1617,Curtin John A.18,Myhre Ronny19,Huikari Ville20,Joro Raimo21,Kerkhof Marjan122,Warrington Nicole M.2324,Pitkänen Niina25,Ntalla Ioanna2627,Horikoshi Momoko2829,Veijola Riitta30,Freathy Rachel M.31,Teo Yik-Ying323334,Barton Sheila J.35,Evans David M.824,Kemp John P.824,St Pourcain Beate83637,Ring Susan M.836,Davey Smith George8,Bergström Anna9,Kull Inger3839,Hakonarson Hakon104041,Mentch Frank D.10,Bisgaard Hans4,Chawes Bo4,Stokholm Jakob4,Waage Johannes4,Eriksen Patrick4,Sevelsted Astrid4,Melbye Mads1142,van Duijn Cornelia M.1,Medina-Gomez Carolina1343,Hofman Albert13,de Jongste Johan C.23,Taal H. Rob12,Uitterlinden André G.1343,Armstrong Loren L.1213,Eriksson Johan14,Palotie Aarno14444546,Bustamante Mariona56747,Estivill Xavier674748,Gonzalez Juan R.567,Llop Sabrina649,Kiess Wieland15,Mahajan Anubha28,Flexeder Claudia17,Tiesler Carla M.T.1617,Murray Clare S.18,Simpson Angela18,Magnus Per50,Sengpiel Verena51,Hartikainen Anna-Liisa52,Keinanen-Kiukaanniemi Sirkka20,Lewin Alexandra53,Da Silva Couto Alves Alexessander53,Blakemore Alexandra I.54,Buxton Jessica L.54,Kaakinen Marika205355,Rodriguez Alina5356,Sebert Sylvain20,Vaarasmaki Marja57,Lakka Timo215859,Lindi Virpi21,Gehring Ulrike60,Postma Dirkje S.2261,Ang Wei23,Newnham John P.23,Lyytikäinen Leo-Pekka6263,Pahkala Katja2524,Raitakari Olli T.2564,Panoutsopoulou Kalliope65,Zeggini Eleftheria65,Boomsma Dorret I.666768,Groen-Blokhuis Maria666768,Ilonen Jorma6970,Franke Lude71,Hirschhorn Joel N.727374,Pers Tune H.727375,Liang Liming76,Huang Jinyan7677,Hocher Berthold787980,Knip Mikael817682,Saw Seang-Mei328384,Holloway John W.85,Melén Erik939,Grant Struan F.A.104041,Feenstra Bjarke11,Lowe William L.1213,Widén Elisabeth14,Sergeyev Elena15,Grallert Harald8687,Custovic Adnan18,Jacobsson Bo1951,Jarvelin Marjo-Riitta2053558889,Atalay Mustafa21,Koppelman Gerard H.2290,Pennell Craig E.23,Niinikoski Harri2591,Dedoussis George V.27,Mccarthy Mark I.282992,Frayling Timothy M.31,Sunyer Jordi56748,Timpson Nicholas J.8,Rivadeneira Fernando1343,Bønnelykke Klaus4,Jaddoe Vincent W.V.123, ,

Affiliation:

1. Department of Epidemiology,

2. Department of Paediatrics,

3. The Generation R Study Group,

4. Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark,

5. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,

6. CIBER Epidemiología y Salud Pública (CIBERESP), Spain,

7. Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain,

8. MRC Integrative Epidemiology Unit ,

9. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,

10. Center for Applied Genomics, Abramson Research Center,

11. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark,

12. Division of Endocrinology, Metabolism and Molecular Medicine,

13. Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA,

14. Institute for Molecular Medicine Finland,

15. Center of Pediatric Research, University Hospital Center Leipzig, University of Leipzig, Leipzig, Germany,

16. Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany,

17. Institute of Epidemiology I,

18. Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK,

19. Division Epidemiology, Department Genes and Environment,

20. Institute of Health Sciences,

21. Institute of Biomedicine, Physiology,

22. Groningen Research Institute for Asthma and COPD,

23. School of Women's and Infants’ Health, The University of Western Australia, Perth, Australia,

24. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia,

25. Research Centre of Applied and Preventive Cardiovascular Medicine,

26. Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK,

27. Department of Nutrition and Dietetics, Harokopio University of Athens, Athens 11527, Greece,

28. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK,

29. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK,

30. Department of Pediatrics, Medical Research Center,

31. University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK,

32. Saw Swee Hock School of Public Health,

33. Life Science Institute, National University of Singapore, Singapore,

34. Genome Institute of Singapore, Agency for Science, Technology and Research,

35. MRC Lifecourse Epidemiology Unit,

36. Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine,

37. School of Oral and Dental Sciences, University of Bristol, Bristol, UK,

38. Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden,

39. Sachs’ Children's Hospital, Stockholm, Sweden,

40. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,

41. Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA,

42. Department of Medicine, Stanford School of Medicine, Stanford, USA,

43. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,

44. Analytic and Translational Genetics Unit, Department of Medicine,

45. Program in Medical and Population Genetics,

46. Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA,

47. Centre for Genomic Regulation (CRG), Barcelona, Spain,

48. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain,

49. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Valencia, Spain,

50. Division Epidemiology, Norwegian Institute of Public Health, Oslo, Norway,

51. Department Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden,

52. Institute of Clinical Medicine/Obstetrics and Gynecology,

53. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health,

54. Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine, Imperial College, London W12 0NN, UK,

55. Biocenter Oulu, University of Oulu, Oulu, Finland,

56. Department of Psychology, Mid Sweden University, Östersund, Sweden,

57. Department of Obstetrics and Gynecology and MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland,

58. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland,

59. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland,

60. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands,

61. Department of Pulmonology,

62. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland,

63. Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland,

64. Department of Clinical Physiology and Nuclear Medicine,

65. Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1HH, UK,

66. Department of Biological Psychology, VU University, Amsterdam, The Netherlands,

67. EMGO Institute for Health and Care Research, Amsterdam, The Netherlands,

68. Neuroscience Campus Amsterdam, The Netherlands,

69. Immunogenetics Laboratory, University of Turku, Turku, Finland,

70. Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland,

71. Department of Genetics, University of Groningen, University Medical Centre Groningen, The Netherlands,

72. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, USA,

73. Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA,

74. Department of Genetics, Harvard Medical School, USA,

75. Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Denmark,

76. Department of Pediatrics, Tampere University Hospital, Tampere, Finland,

77. Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China,

78. Institute of Nutritional Science, University of Potsdam, Germany,

79. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China,

80. Center for Cardiovascular Research/Institute of Pharmacology, Charité, Berlin, Germany,

81. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland,

82. Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland,

83. Singapore Eye Research Institute, Singapore,

84. Duke-NUS Graduate Medical School, Singapore,

85. Human Genetics and Genomic Medicine, Human Development & Health, Faculty of Medicine, University of Southampton, UK,

86. Institute of Epidemiology II,

87. Research Unit for Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany,

88. Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220, Oulu 90029 OYS, Finland,

89. Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, Oulu FI-90101, Finland and

90. Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands,

91. Department of Pediatrics, Turku University Hospital, Turku, Finland,

92. Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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