Nanoparticles loaded with procyanidin B2-3′-O-gallate from grape seed: preparation, characterization and antioxidant activity

Author:

Wu Wenxin,Zhang Shuting,Tang Yuanyuan,Zhang Xiangrong,Sun Baoshan

Abstract

The aim of this study was to prepare nanoparticles of grape seed procyanidin B2-3′-O-gallate by chitosan-sodium alginate. The encapsulation system was characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC), and its biological activity was analyzed by cell-level antioxidant capacity. The results showed that the particle size of nano-carrier was 160~201nm, the B2-3′-O-gallate was well embedded, and the encapsulation efficiency of B2-3′-O-gallate was 93.5%. In vitro digestion experiments suggested that the release of B2-3′-O-gallate was significantly controlled by chitosan-sodium alginate nano-system through anomalous diffusion mechanism, and at about 72-78% of B2-3′-O-gallate was retained under gastrointestinal (GI) condition. Besides, the cytotoxicity results expressed that B2-3′-O-gallate chitosan nanoparticles had obvious protective effect on human HepG2 cells induced by hydrogen peroxide. This work provides a promising way to control the delivery and enhances the biological activity of galloylated procyanidins – one of the most important group of bioactive polyphenols of the grape pomace.

Publisher

EDP Sciences

Subject

Horticulture,Food Science

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