Analysis of Novel Schiff Base-Fe Complexes Against Breast Cancer Cells’ Viability

Abstract

Two potential novels Schiff base iron (Fe) complexes Fe-L2 and Fe-L3 (where L2= N, N'-bis (o-hydroxyacetophenone) ethylenediamine and L3= N, N'-bis (o-hydroxybenzaldehyde) phenylenediamine) were synthesized from interaction a hot methanolic solution of each ligand L2 or L3 (0.01mole) with the appropriate amount of Fe (NO3)3.9H2O metal salt (0.01mole). This study investigated the cytotoxicity induced by both complexes (0.1 to 100 µg/ml) in MCF-7 and MDA-MB 231 cell lines. After 24 hours of treatment, the cell viabilities of both MCF-7 and MDA-MB-231 cells were linearly proportional to the Fe-L2 concentrations. A higher concentration of Fe-L2 would cause higher cell killings. On the other hand, most of the Fe-L3 concentrations caused total cell deaths for both cell lines, except for the lowest concentration (0.1 µg/ml). Fe-L2 and Fe-L3 also caused lower cell viability of MDA-MB-231 cells compared to MCF-7 cells. Overall, the obtained Fe-L3 is more toxic than Fe-L2 in breast cancer cells. It is suggested that the Fe-L3 is an excellent agent against breast cancer cells; meanwhile, the Fe-L2 is biocompatible and a good support in medical applications, especially as a radiosensitizer in radiotherapy.