Research on Structural Modification and Structure-Activity Relationship about Anti-Tumor of Polysaccharides from Plants

Abstract

Since it was found that Zymosan had activity of anti-tumor at 1960s, polysaccharides have attracted more and more researchers’ attentions in the field of anti-tumor. In recent years, researches on polysaccharides get many outstanding achievements in anti-tumor field. Polysaccharides from plants have been proved that their activity of anti-tumor is related to their molecular structures very closely. The critical factors that influence bioactivities of polysaccharides are as follows: polysaccharide’s molecular weight, saccharide unit of polysaccharide’s main-chain, configuration of glycosidic bond, degree of branch, spatial structure, and functional group modification, etc. We analyze and summarize structural modification and structure-activity relationship about anti-tumor of polysaccharides from plants in this article, based on our study and associated with other researches’ progress in the world.