Milk Fat Globule Membrane Proteins. 8. Fatty Acid-Binding Protein (FABP)

Author:

Elchaninov Vadim1

Affiliation:

1. Federal Altai Scientific Centre of Agro-BioTechnologies

Abstract

This article continues a series of reviews about the structure and functions of milk fat globule membrane (MFGM) proteins in cow’s milk. This installment introduces publications on the biochemistry of fatty acid binding protein (FABP), which is a polypeptide component of MFGM. The article gives a brief history of its discovery, as well as profiles the proteins that bind hydrophobic ligands and describes the methods of FABP identification in MFGM preparations. Other aspects of FABP studies include: isoforms and modern nomenclature; amino acid sequence and reactions to post-translational modification; spatial organization; mechanisms for binding fatty acids to lipids; well-investigated and hypothesized physiological functions; the effect of haplotypes on milk fatty acids, yield, and protein content.

Publisher

Kemerovo State University

Reference20 articles.

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2. Böhmer, F.-D. Identification of a polypeptide growth inhibitor from bovine mammary gland. Sequence homology to fatty acid- and retinoid-binding proteins / F.-D. Böhmer [et al.] // The Journal of biological chemistry. 1987. V. 262. P. 15137–15143., Böhmer, F.-D. Identification of a polypeptide growth inhibitor from bovine mammary gland. Sequence homology to fatty acid- and retinoid-binding proteins / F.-D. Böhmer [et al.] // The Journal of biological chemistry. 1987. V. 262. P. 15137–15143.

3. Böhmer, F.-D. Purification of a growth inhibitor for Ehrlich ascites mammary carcinoma cells from bovine mammary gland / F.-D. Böhmer [et al.] // Experimental cell research. 1984. Vol. 150(2). 466–476. https://doi.org/10.1016/0014-4827(84)90591-3, Böhmer, F.-D. Purification of a growth inhibitor for Ehrlich ascites mammary carcinoma cells from bovine mammary gland / F.-D. Böhmer [et al.] // Experimental cell research. 1984. Vol. 150(2). 466–476. https://doi.org/10.1016/0014-4827(84)90591-3

4. Bansal, M. P. Expression of fatty acid binding proteins in the developing mouse mammary gland / M. P. Bansal, D. Medina // Biochemical and biophysical research communications. 1993. Vol. 191(1). 61–69. https://doi.org/10.1006/bbrc.1993.1184, Bansal, M. P. Expression of fatty acid binding proteins in the developing mouse mammary gland / M. P. Bansal, D. Medina // Biochemical and biophysical research communications. 1993. Vol. 191(1). 61–69. https://doi.org/10.1006/bbrc.1993.1184

5. Specht, B. Mammary derived growth inhibitor is not a distinct protein but amix of heart–type and adipocytetype fatty acid–binding protein / B. Specht [et al.] // The Journal of biological chemistry. 1996. Vol. 271(33). 19943–19949. https://doi.org/10.1074/jbc.271.33.19943, Specht, B. Mammary derived growth inhibitor is not a distinct protein but amix of heart–type and adipocytetype fatty acid–binding protein / B. Specht [et al.] // The Journal of biological chemistry. 1996. Vol. 271(33). 19943–19949. https://doi.org/10.1074/jbc.271.33.19943

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