Affiliation:
1. Department of Anesthesiology, Shandong Provincial Hospital Affiliated With Shandong UniversityJinan, ShandongP.R. China
2. Department of Anesthesiology, Ningjin Peoples HospitalNingjin, ShandongP.R. China
Abstract
This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63 and to explore the possible relationship between DEX and miR-520-3p in OS. The results showed that DEX could upregulate miR-520-3p, which directly targeted AKT1. Additionally,
miR-520-3p also inhibited MG63 cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT, p-mTOR, and p-ERK1/2. DEX can inhibit OS cell proliferation and migration and promote apoptosis by upregulating the expression level of miR-520a-3p. DEX may
serve as a potential therapeutic agent in OS treatment, and miR-520a-3p may be a potential target in the therapy of OS.
Subject
Cancer Research,Oncology,General Medicine
Cited by
27 articles.
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