BACKGROUND
Along with the rapid development of global aging society, the mobile and health digital market has expanded a lot. There are numerous numbers of Mobile Medical Applications emerged on the Internet market, aiming to help patients with chronic diseases achieve the goal of medication safety
OBJECTIVE
Based on the medication safety action proposed by WHO, the effect of Mobile Medical Applications on the medication safety with chronic disease patients was explored from three aspects: whether Mobile Medical Applications can improve the willingness to report adverse drug events, improve patients' medication adherence and reduce medication errors, so we want to verify our hypothesis via systematic review and meta-analysis.
METHODS
We strictly followed PRISMA for meta-analysis, including literature search, inclusion and exclusion, data extraction, quality assessment, statistical analysis and subgroup analysis.
RESULTS
Our study ultimately included 8 studies from 5 countries (China, U.S, France, Canada, Spain)and time from 2014 to 2021, which Mobile Medical Applications could increase ADE reporting willingness [RR= 2.59,95%CI (1.26-5.30),P＜0.01] and significantly improve medication adherence[RR= 1.17,95%CI (1.04-1.31),P＜0.01], but had little effect on reducing medication errors[RR= 0.41,95%CI (0.13-1.33),P＞0.05].
CONCLUSIONS
To explore the associated reasons for the low willingness to report ADE and encourage the use of comprehensive tools to assess patient medication adherence, and analyze potential reasons why Mobile Medical Applications does not reduce medication errors.
CLINICALTRIAL
This systematic review has registered in PROSPERO(an international database of prospectively registered systematic reviews), and register number is CRD42022322072.