ACTIONS OF DROSERA SP IN DENTISTRY DISEASES. PHITOCHEMICAL COMPONENTS, PHARMACOLOGICAL ACTIONS

Abstract

The aim of this review is to establish the main phytoconstituents of Drosera species and to find interrelations between them and the pharmacological action of the extracts. We paid special attention to the possibilities of using the Drosera species in the field of dentistry. To achieve the proposed goal, a series of scientific publications on the chemical composition, pharmacological action and medicinal use of Drosera species were identified and evaluated. The analysis took into account different criteria: the establishment of the phytoconstituents, the chemical methods of isolation, the analysis and the pharmacological particularities, and the use in dental field. Results showed that Drosera species are rich in flavonoids, especially flavonols (gossypin and gossiptrin) and their glycosides (quercetin, isoquercetin, hyperoside, astralgin), naphthoquinone derivatives (plumbagin, naphthoquinone) and tannins (ellagic acid, dimethylellagic acid). These components are responsible for anti-inflammatory, antispasmodic, antioxidant and anti tumoral activity. The first studies related to the anti-inflammatory action are recorded in 2002 by Kolodziej [23] and refers to Drosera peltata. The latest studies on the anti-inflammatory action are those from 2022 led by Hake [22] and these lead to a better understanding of the mechanism of the anti-inflammatory action , respectively of its natural compounds ( quercetin , isoquercetin and hyperoside ) functioning as neutrophyl inhibitors. Drosera sp. can be used in dental diseases due to the anti-inflammatory and antibacterial action of its bioactive components.