Abstract
Oral drug delivery is still the preferred method for administering many medications. Recent technological advancements have led to the development of orally disintegrating drugs, which offer improved patient compliance and convenience. Orodispersible(ODTs) drugs are a unique dosage form that dissolves in the mouth within 1-3 min without the need for chewing or water. Over the past three decades, orodispersible drugs have gained popularity as an alternative to traditional drugs due to their increased patient compliance, solubility, and stability. This new technology meets both the pharmaceutical and patient demands and provides a comfortable dosage method for pediatric, geriatric, and psychiatric patients with dysphagia. Natural substances are preferred over synthetic ones because they are more accessible, less expensive, non-toxic, and chemically inert. Natural polymers, such as locust bean gum, banana powder, mango peel pectin, and Mangifera indica gum, enhance drug characteristics and are used as binders, diluents, and super disintegrants to speed up disintegration, increase solubility, and provide supplements. Manufacturers are increasingly using natural polymers due to various issues with medication release and adverse effects. This review article views the development of ODTs, challenges in formulation, new ODT technologies, and our suspects.
Publisher
Innovare Academic Sciences Pvt Ltd
Reference119 articles.
1. Das SK. Solid dispersions: an approach to enhance the bioavailability of poorly water-soluble drugs. IJPPT. 2013:37-46. doi: 10.47893/IJPPT.2013.1006.
2. Sharma D, Soni M, Kumar S, Gupta GD. Solubility enhancement-eminent role in poorly soluble drugs. Res J Pharm Technol. 2009;2(2):220-4. doi: 10.5958/0974-360X.2009.00364.6.
3. Patel T, Patel L, Patel T, Makwana S, Patel T. Enhancement of dissolution of fenofibrate by solid dispersion technique. Int J Res Pharm Sci. 2010;1(2):127-32. doi: 10.7897/2230-8407.01218p.
4. Weuts I, Kempen D, Verreck G, Peeters J, Brewster M, Blaton N. Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage. Eur J Pharm Sci. 2005;25(4-5):387-93. doi: 10.1016/j.ejps.2005.04.011. PMID 15894472.
5. Bramhmankar DM, Jaiswal SB. Biopharmaceutics and pharmacokinetics-a treatise. 2nd ed Vallabh Prakashan;2005. p. 24-30, 314-36.