Abstract
Diabetic nephropathy (DN) is the most common complication of diabetes mellitus (DM). It is characterized by high blood glucose levels or hyperglycemia and is accompanied by changes in lipid, carbohydrate, and protein metabolism which can lead to an increased risk of complications due to vascular disease. DN is probably the most insidious among these complications, causing substantial morbidity and mortality. In this article, we will review the literature on animal models of diabetes. We will discuss several species as animal models for Type 1 and 2 diabetes, including zebrafish, rabbits, mice, rats, and rat models. This article also provides various methods used in research with model animals and presents the required result for studying diabetic DN.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference113 articles.
1. Alipour A, Zare H, Poursharifi H, Aerab Sheibani K, Ardekani MA. The intermediary role of self-efficacy in relation with stress, glycosylated haemoglobin and health-related quality of life in patients with Type2 diabetes. Iran J Public Health 2012;41:76-80.
2. Ardiana L, Sauriasari R, Elya B. Antidiabetic activity studies of white tea (Camellia sinensis (L.) O. Kuntze) ethanolic extracts in streptozotocin-nicotinamide induced diabetic rats. Pharmacogn J 2018;10:186-9.
3. Hirano T. Pathophysiology of diabetic dyslipidemia. J Atheroscler Thromb 2018;25:771-82.
4. Azeez A, Tomy S, Ali Abdalla FM, Suresh R, Johnson B. Antidiabetic effect of polyherbal formulation “Kathakakhadiradi Kashyam” in streptozotocin induced diabetic rats. J Young Pharm 2016;8:496-9.
5. Azushima K, Gurley SB, Coffman TM. Modelling diabetic nephropathy in mice. Nat Rev Nephrol 2017;14:48-56. doi: 10.1038/ nrneph.2017.142