Affiliation:
1. From Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland
Abstract
A subset of CD4+CD11c−CD3− blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4+ CD11c−CD3− cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
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