A HISTOLOGICAL STUDY OF INFECTIOUS CANINE HEPATITIS BY MEANS OF FLUORESCENT ANTIBODY-Reference-Cited by-同舟云学术

A HISTOLOGICAL STUDY OF INFECTIOUS CANINE HEPATITIS BY MEANS OF FLUORESCENT ANTIBODY

Published:1953-07-01 Issue:1 Volume:98 Page:13-20
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Coffin David L.¹,Coons Albert H.¹,Cabasso Victor J.¹

Affiliation:

1. From the Department of Pathology, Angell Memorial Animal Hospital, Boston; the Departments of Pathology and of Bacteriology and Immunology, Harvard Medical School, Boston; and the Lederle Laboratories Division of the American Cyanamid Company, Pearl River

Abstract

A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen. The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, with the gradual formation of larger granules. Subsequently there appear the homogeneous inclusion bodies characteristic of this infection.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/98/1/13/1185220/13.pdf

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