Organ-specific lymphatic vasculature: From development to pathophysiology

Author:

Petrova Tatiana V.12ORCID,Koh Gou Young34

Affiliation:

1. Department of Fundamental Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland

2. Division of Experimental Pathology, Vaud University Hospital Center, University of Lausanne, Lausanne, Switzerland

3. Center for Vascular Research, Institute for Basic Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

4. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

Abstract

Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm’s canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.

Funder

Swiss National Science Foundation

MEDIC Foundation

Emma Muschamp Foundation

Fondation Leenaards

TheraLymph ERA-NET E-Rare Research Program

Commission for Technology and Innovation

Swiss Cancer League

Human Frontier Science Program

Ministry of Science and Information and Communications Technology

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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