Microbial therapeutics: New opportunities for drug delivery-Reference-Cited by-同舟云学术

Microbial therapeutics: New opportunities for drug delivery

Published:2019-04-26 Issue:5 Volume:216 Page:1005-1009
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Jimenez Miguel¹^ORCID,Langer Robert¹²³,Traverso Giovanni⁴⁵^ORCID

Affiliation:

1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA

2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA

3. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA

4. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

5. Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Abstract

With >40 clinical trials underway, we are nearing the first FDA-approved live microbial therapeutic. Here, Giovanni Traverso, MIT and Harvard Medical School Assistant Professor, and colleagues Miguel Jimenez and Institute Professor Robert Langer from MIT discuss the significant challenges of administering live microorganisms to patients and the opportunities for drug delivery of these new complex therapeutics.

Funder

Translational Research Institute for Space Health

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/216/5/1005/1173257/jem_20190609.pdf

Reference15 articles.

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2. Food and Drug Administration . 2013. Vivotif Typhoid Vaccine Live Oral Ty21a. Version: September 2013. Available at: https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094070.htm

3. Food and Drug Administration . 2016a. Fed. Regist. https://www.federalregister.gov/d/2016-15664.

4. Food and Drug Administration . 2016b. Fed. Regist. https://www.federalregister.gov/d/2016-04372

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