Affiliation:
1. Institute for Molecular Bioscience and Institute for Molecular Bioscience Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, Australia
Abstract
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within signaling platforms called inflammasomes. By inducing pyroptosis, inflammasomes can also drive the release of the alarmin IL-1α. Recent advances have transformed our mechanistic understanding of inflammasome signaling, cell death decisions, and cytokine activation and secretion. Here, we provide an updated view of inflammasome signaling; mechanisms underpinning IL-1α, IL-1β, IL-18, and IL-37 maturation and release; and the functions of these cytokines in protective and pathological inflammation.
Funder
National Health and Medical Research Council
Australian Government
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
232 articles.
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