Risk of Zika microcephaly correlates with features of maternal antibodies-Reference-Cited by-同舟云学术

Risk of Zika microcephaly correlates with features of maternal antibodies

Published:2019-08-14 Issue:10 Volume:216 Page:2302-2315
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Robbiani Davide F.¹^ORCID,Olsen Priscilla C.¹²,Costa Federico³⁴,Wang Qiao⁵^ORCID,Oliveira Thiago Y.¹,Nery Nivison⁶,Aromolaran Adeolu³,do Rosário Mateus S.⁷,Sacramento Gielson A.⁶,Cruz Jaqueline S.⁶,Khouri Ricardo⁶,Wunder Elsio A.³^ORCID,Mattos Adriana⁷,de Paula Freitas Bruno⁷⁸,Sarno Manoel⁴,Archanjo Gracinda⁷,Daltro Dina⁷,Carvalho Gustavo B.S.⁷,Pimentel Kleber⁷,de Siqueira Isadora C.⁶^ORCID,de Almeida João R.M.⁴^ORCID,Henriques Daniele F.⁹,Lima Juliana A.⁹,Vasconcelos Pedro F.C.⁹,Schaefer-Babajew Dennis¹,Azzopardi Stephanie A.¹⁰,Bozzacco Leonia¹⁰,Gazumyan Anna¹,Belfort Rubens⁸^ORCID,Alcântara Ana P.¹¹,Carvalho Gustavo¹¹,Moreira Licia¹¹^ORCID,Araujo Katiaci¹²,Reis Mitermayer G.⁶³⁴,Keesler Rebekah I.¹³,Coffey Lark L.¹⁴,Tisoncik-Go Jennifer¹⁵¹⁶¹⁷,Gale Michael¹⁵¹⁶¹⁷¹⁸^ORCID,Rajagopal Lakshmi¹⁸¹⁹²⁰,Adams Waldorf Kristina M.¹⁵¹⁶¹⁸²¹,Dudley Dawn M.²²^ORCID,Simmons Heather A.²³,Mejia Andres²³^ORCID,O’Connor David H.²²,Steinbach Rosemary J.²⁴,Haese Nicole²⁵²⁶^ORCID,Smith Jessica²⁶,Lewis Anne²⁷^ORCID,Colgin Lois²⁵,Roberts Victoria²⁴,Frias Antonio²⁴²⁸,Kelleher Meredith²⁴^ORCID,Hirsch Alec²⁵²⁶,Streblow Daniel N.²⁵²⁶,Rice Charles M.¹⁰,MacDonald Margaret R.¹⁰^ORCID,de Almeida Antonio R.P.⁴,Van Rompay Koen K.A.¹³¹⁴^ORCID,Ko Albert I.⁶³^ORCID,Nussenzweig Michel C.¹²⁹^ORCID

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY

2. Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

3. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT

4. Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil

5. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

6. Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil

7. Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil

8. Universidade Federal de São Paulo, São Paulo, Brazil

9. Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil

10. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY

11. Hospital Santo Amaro, Salvador, Bahia, Brazil

12. Hospital Aliança, Salvador, Bahia, Brazil

13. California National Primate Research Center, University of California, Davis, Davis, CA

14. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA

15. Washington National Primate Research Center, Seattle, WA

16. Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA

17. Department of Immunology, University of Washington, Seattle, WA

18. Department of Global Health, University of Washington, Seattle, WA

19. Department of Pediatrics, University of Washington, Seattle, WA

20. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA

21. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA

22. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI

23. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI

24. Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR

25. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR

26. Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR

27. Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR

28. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR

29. Howard Hughes Medical Institute, The Rockefeller University, New York, NY

Abstract

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

Funder

National Institutes of Health

Rockefeller University

Fundação de Amparo à Pesquisa do Estado da Bahia

Food and Drug Administration

Conselho Nacional de Desenvolvimento Cientifico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Pew Latin American Fellows Program in the Biomedical Sciences

Studienstiftung des Deutschen Volkes

Wellcome Trust

Howard Hughes Medical Institute

Publisher