The nature of human IL-6-Reference-Cited by-同舟云学术

The nature of human IL-6

Published:2019-06-24 Issue:9 Volume:216 Page:1969-1971
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Puel Anne¹²^ORCID,Casanova Jean-Laurent¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France

2. Paris Descartes University, Imagine Institute, Paris, France

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY

4. Howard Hughes Medical Institute, New York, NY

5. Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France

Abstract

Countless functions have been attributed experimentally to IL-6. In this issue of JEM, Spencer et al. (https://doi.org/10.1084/jem.20190344) reveal essential, nonredundant functions of human IL-6. Patients with genetic deficiencies of the IL-6 receptor suffer from “hyper IgE syndrome.”

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/216/9/1969/1173123/jem_20191002.pdf

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1. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

2. Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

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