Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment

Author:

Prinz Immo123ORCID,Sandrock Inga1,Mrowietz Ulrich4

Affiliation:

1. Institute of Immunology, Hannover Medical School, Hannover, Germany

2. Centre for Individualized Infection Medicine, Hannover, Germany

3. Cluster of Excellence RESIST - Resolving Infection Susceptibility (EXC 2155), Hannover Medical School, Hannover, Germany

4. Psoriasis Center at the Department of Dermatology and Comprehensive Center for Inflammation Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Germany

Abstract

The IL-17 cytokine family comprising IL-17A to IL-17F and receptor subunits IL-17RA to IL-17RE represents a genetically ancient intercellular network regulating local tissue homeostasis. Its pivotal role in antifungal defense and its central position in the pathogenesis of inflammatory diseases including psoriasis were discovered only relatively late in the early 2000s. Since the connection of dysregulated IL-17 and psoriasis pathogenesis turned out to be particularly evident, a number of monoclonal antibodies targeting IL-17 pathways have been approved and are used as first line treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis, and further agents are currently in clinical development.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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