Fibroblast heterogeneity in the cancer wound-Reference-Cited by-同舟云学术

Fibroblast heterogeneity in the cancer wound

Published:2014-07-28 Issue:8 Volume:211 Page:1503-1523
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Öhlund Daniel¹,Elyada Ela¹,Tuveson David¹

Affiliation:

1. D. Öhlund, E. Elyada, and D. Tuveson are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

Abstract

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/211/8/1503/1213831/jem_20140692.pdf

Reference263 articles.

1. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid;Ahrens;Oncogene.,2001

2. Targeting the TGFβ signalling pathway in disease;Akhurst;Nat. Rev. Drug Discov.,2012

3. Molecular characterization of the tumor microenvironment in breast cancer;Allinen;Cancer Cell.,2004

4. Stromal disrupting effects of nab-paclitaxel in pancreatic cancer;Alvarez;Br. J. Cancer.,2013

5. On the origin of cancer-associated fibroblasts;Anderberg;Cell Cycle.,2009

Cited by 657 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A prognostic model based on Scissor+ cancer associated fibroblasts identified from bulk and single cell RNA sequencing data in head and neck squamous cell carcinoma;Cellular Signalling;2024-02

2. Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells;Cell Death & Disease;2024-01-30

3. Cancer-Associated Fibroblast Heterogeneity in Malignancy with Focus on Oral Squamous Cell Carcinoma;International Journal of Molecular Sciences;2024-01-21

4. ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts;Molecular Carcinogenesis;2024-01-04

5. The importance of cancer-associated fibroblasts in targeted therapies and drug resistance in breast cancer;Frontiers in Oncology;2024-01-04