THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI

Author:

Smithburn Kenneth C.1,Sabin Florence R.1

Affiliation:

1. From the Laboratories of The Rockefeller Institute for Medical Research

Abstract

1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to the amount of material injected. 2. The reaction induced by the lipoid is much less extensive and much simpler when the material is neutralized with alkali. Neutralization of the acetone-soluble fat, or of phthioic acid, does not diminish the tuberculogenic property. 3. Acetone-soluble fat from streptococci is likewise extremely irritating but does not produce tubercular tissue.

Publisher

Rockefeller University Press

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. SOME BIOLOGICAL PROPERTIES OF BCG AFTER THE EXTRACTION OF LIPIDS: THE POWER TO IRRITATE TISSUES, THE ABILITY TO PREPARE FOR AND TO EVOKE BAIL'S PHENOMENON, AND THE POWER TO SENSITIZE TO TUBERCULIN;Canadian Journal of Microbiology;1958-08-01

2. Chimie des lipides bactériens;Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progres dans La Chimie des Substances Organiques Naturelles;1953

3. Pathological Studies on Acetone‐Soluble Fat from Mycobacteria: REPORT I;Acta Pathologica Japonica;1953-01

4. Relative Danger of Infected Deciduous and Permanent Teeth;The Journal of the American Dental Association;1951-06

5. Studies of Phthioic Acid. VIII;YAKUGAKU ZASSHI;1950

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