The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Author:
Affiliation:
1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX
2. Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX
3. Howard Hughes Medical Institute, Chevy Chase, MD
Abstract
Funder
Welch Foundation
Cancer Prevention and Research Institute of Texas
Lupus Research Alliance
Cancer Research Institute
Howard Hughes Medical Institute
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Link
http://rupress.org/jem/article-pdf/215/5/1287/1170498/jem_20180139.pdf
Reference163 articles.
1. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING;Ablasser;Nature.,2013
2. Chemokine signaling via the CXCR2 receptor reinforces senescence;Acosta;Cell.,2008
3. STING manifests self DNA-dependent inflammatory disease;Ahn;Proc. Natl. Acad. Sci. USA.,2012
4. Intrinsic self-DNA triggers inflammatory disease dependent on STING;Ahn;J. Immunol.,2014
5. Inflammation-driven carcinogenesis is mediated through STING;Ahn;Nat. Commun.,2014
Cited by 758 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression;Current Problems in Cardiology;2024-02
2. Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway;European Journal of Pharmacology;2024-02
3. Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo;Food and Chemical Toxicology;2024-02
4. Activation of STING by the Novel Liposomal TLC388 Enhances the Therapeutic Response to Anti-PD-1 Antibodies in Combination with Radiotherapy;2024-01-30
5. Crosstalk between inflammasome sensors and DNA damage response pathways;The FEBS Journal;2024-01-25
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3