Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor

Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

Published:1999-07-01 Issue:1 Volume:190 Page:141-144
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Aifantis Iannis¹,Feinberg Jacqueline¹,Fehling Hans Jörg²,Di Santo James P.³,von Boehmer Harald¹

Affiliation:

1. From the Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, F-75730 Paris, France

2. Basel Institute for Immunology, CH-4005 Basel, Switzerland

3. INSERM U429, CH-4005 Basel, Switzerland

Abstract

We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25+44− thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/190/1/141/1121998/99-0313.pdf

Reference18 articles.

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