Persistent cellular immunity to SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Persistent cellular immunity to SARS-CoV-2 infection

Published:2021-01-27 Issue:4 Volume:218 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Breton Gaëlle¹^ORCID,Mendoza Pilar¹^ORCID,Hägglöf Thomas¹^ORCID,Oliveira Thiago Y.¹^ORCID,Schaefer-Babajew Dennis¹^ORCID,Gaebler Christian¹^ORCID,Turroja Martina¹^ORCID,Hurley Arlene²^ORCID,Caskey Marina¹^ORCID,Nussenzweig Michel C.¹³^ORCID

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY

2. Hospital Program Direction, The Rockefeller University, New York, NY

3. Howard Hughes Medical Institute, Baltimore, MD

Abstract

SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen–specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.

Funder

National Institutes of Health

Swedish Research Council

Howard Hughes Medical Institute

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/doi/10.1084/jem.20202515/1408850/jem_20202515.pdf

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