MICROBIOME AND REACTIVE OXYGEN SPECIES – SYNERGETIC FACTORS OF TUMOR PROGRESSION

Abstract

Summary. The tumor microenvironment is a unique composition of cellular and soluble factors associated with the development of the tumor process. These factors include stromal and endothelial cells, cells of the immune system, components of the extracellular matrix, and cytokines. Recently, the microbiome, which is one of the key components for maintaining the homeostasis of any organs and tissues of the human body, was included as an element of the tumor microenvironment. Cellular elements of the microenvironment are interconnected and interdependent. Such influence is implemented with the involvement of soluble factor, among which the role of the “two-face Janus” is played by reactive oxygen species (ROS). The review provides data on the importance of ROS for the activity of immune system cells and the microbiome. Mechanisms of influence of the microbiome with the participation of ROS on the tumor process were considered.