SARS-CoV-2 infection and thyroid dysfunction in children
-
Published:2023-07-10
Issue:3
Volume:95
Page:12-21
-
ISSN:2409-4943
-
Container-title:The Ukrainian Biochemical Journal
-
language:
-
Short-container-title:Ukr.Biochem.J.
Author:
Kozak K. V., ,Pavlyshyn H. A.,Avramenko I. Y.,Dyvonyak O. M.,Shevchuk O. O.,Hlushko K. T., , , , ,
Abstract
The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity as well as to determine optimal cut-off values for screening for thyroid disorders in children. A total number of 90 children aged from 1 month to 17 years were involved in the study. Patients with known thyroid disease were not recruited for the research. A thyroid panel was assessed for all participants that included: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis was done using the computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) in 14.10% of SARS-CoV-2 infected children more often among patients with severe COVID-19 and multisystem inflammatory syndrome (33.33%) compared to mild COVID-19 course (6.67%) and moderate disease severity (8.89%) (P < 0.05). Significant correlation relationships were revealed for next values – FT3 and erythrocyte sedimentation rate (ESR) (rs = -0.22; P < 0.05); FT3 and C-reactive protein (CRP) (rs = -0.33; P < 0.05); FT3 and procalcitonin (rs = -0.43; P < 0.05). The next cut-off values for ESS determination were revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l (AUC 0.763); ferritin 84.8 ng/ml (AUC 0.733). Results suggest that pediatricians should pay attention to the endocrine disruptions by COVID-19 in children. Keywords: COVID-19, euthyroid sick syndrome in children, inflammatory markers
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Reference23 articles.
1. Croce L, Gangemi D, Ancona G, Liboà F, Bendotti G, Minelli L, Chiovato L. The cytokine storm and thyroid hormone changes in COVID-19. J Endocrinol Invest. 2021;44(5):891-904. PubMed, PubMedCentral, CrossRef 2. Zheng J, Cui Z, Shi N, Tian S, Chen T, Zhong X, Qiu K, Zhang J, Zeng T, Chen L, Li H. Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19. BMC Endocr Disord. 2021;21(1):228. PubMed, PubMedCentral, CrossRef 3. McCowan R, Wild E, Lucas-Herald AK, McNeilly J, Mason A, Wong SC, Ahmed SF, Shaikh MG. The effect of COVID-19 on the presentation of thyroid disease in children. Front Endocrinol (Lausanne). 2022;13:1014533. PubMed, PubMedCentral, CrossRef 4. Rossetti CL, Cazarin J, Hecht F, Beltrão FEL, Ferreira ACF, Fortunato RS, Ramos HE, de Carvalho DP. COVID-19 and thyroid function: What do we know so far? Front Endocrinol (Lausanne). 2022;13:1041676. PubMed, PubMedCentral, CrossRef 5. Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Cheung CYY , Fong CHY, Kwok STM, Law CY, To KKW, Lam CW , Tan KCB, Woo YC, Hung IFN, Lam KSL. Development of a prediction score (ThyroCOVID) for identifying abnormal thyroid function in COVID-19 patients. J Endocrinol Invest. 2022;45(11):2149-2156. PubMed, PubMedCentral, CrossRef
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|