Affiliation:
1. V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
Abstract
A series of prenylated homoisoflavonoid-coumarin hybrids were synthesised by developed cascade reactions of coumarin Mannich bases with 3-(dimethylamino)-1-(5-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)prop-2-en-1-one. Obtained homoisoflavonoids might have a large potential for further investigations of their bioactivities
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Reference21 articles.
1. An, H.; Eum, S.-J.; Koh, M.; Lee, S.K.; Park, S.B. Diversity-Oriented Synthesis of Privileged Benzopyranyl Heterocycles from s-cis-Enones. J. Org. Chem. 2008, 73, 1752-1761. http://doi.org/10.1021/jo702196f
2. Siddaiah, V.; Rao, C.V.; Venkateswarlu, S.; Krishnaraju, A.V.; Subbaraju, G.V. Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids. Bioorg. Med. Chem. 2006, 14, 2545-2551. https://doi.org/10.1016/j.bmc.2005.11.031
3. Abegaz, B.M.; Mutanyatta-Comar, J.; Nindi, M. Naturally Occurring Homoisoflavonoids: Phytochemistry, Biological Activities and Synthesis. Nat. Prod. Commun. 2007, 2, 475-498. http://doi.org/10.1177/1934578x0700200418
4. Kumar, V.; Nayak, S.K. Homoisoflavonoids: isolation, chemical synthesis strategies and biological activities. J. Pharm. Sci. Res. 2020, 12, 1046-1055.
5. Castelli, M.V.; López, S.N. in Studies in Natural Products Chemistry, edited by Atta-ur-Rahman (Elsevier, 2017), Vol. 54, pp. 315-354. https://doi.org/10.1016/B978-0-444-63929-5.00009-7