Ammonium Chloride: An Efficient and Environmentally benign Catalyst for Knoevenagel Condensation of Carbonyl and Active Methylene Compounds

Author:

Tasqeeruddin S.1,Asiri Yahya I.2,lam M. Mujahid A3

Affiliation:

1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

2. Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

3. Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia

Abstract

In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation of various carbonyl and active methylene compounds in ethanol at a moderate temperature in the presence of a catalytic amount of an efficient, environmentally benign and inexpensive ammonium chloride is reported. Simple reaction procedure, economic and ecofriendly catalyst, mild reaction conditions and good to excellent yield of the products are the characteristic features of this study. The non-extractive workup/purification, economic and environmentally benign catalyst make this operationally straightforward procedure affordable for large scale.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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