Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review-Reference-Cited by-同舟云学术

Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review

Published:2024-09-10 Issue: Volume:12 Page:e18062
ISSN:2167-8359
Container-title:PeerJ
language:en
Short-container-title:

Author:

Cheng Yunhua¹²,Zhu Liling³,Xie Shuangxiong¹²,Lu Binyuan¹²,Du Xiaoyu⁴,Ding Guanjiang¹²,Wang Yan¹²,Ma Linchong²,Li Qingxin²

Affiliation:

1. The First School of Clinical Medicine of Gansu University of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China

2. Department of Thoracic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu Province, China

3. Department of Anesthesiology, Hunan Children’s Hospital, Changsha, Hunan Province, China

4. Medical College of Northwest Minzu University, Northwest Minzu University, Lanzhou, Gansu Province, China

Abstract

Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI. Ferroptosis and mitophagy are both closely related to reactive oxygen species (ROS). Mitophagy can regulate ferroptosis, but the specific relationship between ferroptosis and mitophagy is still unclear. This study summarizes previous research findings on ferroptosis and mitophagy, revealing their involvement in ALI. Examining the functions of mTOR and NLPR3 helps clarify the connection between ferroptosis and mitophagy in ALI, with the goal of establishing a theoretical foundation for potential therapeutic approaches in the future management of ALI.

Funder

Research Project of the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army

Publisher

PeerJ

Link

https://peerj.com/articles/18062.pdf

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