Risk factors for falls in community-dwelling older people with mild cognitive impairment: a prospective one-year study

Author:

Chantanachai Thanwarat12,Taylor Morag E.13ORCID,Lord Stephen R.14,Menant Jasmine14,Delbaere Kim14ORCID,Sachdev Perminder S.56,Kochan Nicole A.6,Brodaty Henry6,Sturnieks Daina L.12

Affiliation:

1. Falls, Balance and Injury Research Centre, Neuroscience Research Australia, Sydney, New South Wales, Australia

2. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

3. Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia

4. School of Population Health, University of New South Wales, Sydney, New South Wales, Australia

5. Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia

6. Faculty of Medicine and Health, University of New South Wales, Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Sydney, New South Wales, Australia

Abstract

Objective Mild cognitive impairment (MCI) is considered an intermediate stage between normal cognitive function and dementia. Fall risk is increased in this group, but there is limited literature exploring specific fall risk factors that may be addressed in fall prevention strategies. The aim of this study was to examine risk factors for falls in older people with MCI, focusing on cognitive, psychological and physical factors. Methods Participants (n = 266, 45% women) were community-dwelling older people aged 70–90 years who met the criteria for MCI. Cognitive, psychological, sensorimotor and physical assessments, physical activity levels, medication use, general health and disability were ascertained at baseline. Falls were monitored prospectively for 12 months. Results During follow-up, 106 (40%) participants reported one or more falls. Poorer visual contrast sensitivity, increased postural sway, lower levels of weekly walking activity, higher levels of depressive symptoms and psychotropic medication use were significantly associated with faller status (≥1 falls) in univariable analyses. Of these factors, poor visual contrast sensitivity, increased postural sway and psychotropic medication use were found to be significant independent predictors of falls in multivariable analysis while controlling for age and sex. No measures of cognitive function were associated with falls. Conclusions Poor visual contrast sensitivity, impaired balance and psychotropic medication use predicted falls in community-dwelling people with MCI. These risk factors may be amenable to intervention, so these factors could be carefully considered in fall prevention programs for this population.

Funder

National Health & Medical Research Council (NHMRC) Program

NHMRC Centre for Research Excellence in the Prevention of Fall-related Injuries

NHMRC Investigator grant

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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