Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine-Reference-Cited by-同舟云学术

Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine

Published:2023-06-29 Issue:2 Volume:15 Page:68-72
ISSN:2008-5117
Container-title:Journal of Cardiovascular and Thoracic Research
language:en
Short-container-title:J Cardiovasc Thorac Res

Author:

Roshanravan Neda¹^ORCID,Ghaffari Samad¹^ORCID,Bastani Sepideh²,Pahlavan Sara³,Asghari Samira⁴,Doustvandi Mohammad Amin⁵,Jalilzadeh- Razin Sepideh⁶,Dastouri Mohammadreza⁷^ORCID

Affiliation:

1. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2. Department of Immunology, Leiden University Medical Science, Leiden, Netherlands

3. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

4. University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

6. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

7. Ankara University Biotechnology Institute and SISBIYOTEK Advanced Research Unit, Gumusdere Yerleskesi, Kecioren, Ankara, Turkey

Abstract

Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine.

Publisher

Maad Rayan Publishing Company

Subject

Cardiology and Cardiovascular Medicine

Link

https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-68.pdf