Utility of serum interleukin-18 (IL-18) as a tumour marker in gastric cancer
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Published:2022-11-14
Issue:5
Volume:42
Page:1079-1082
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ISSN:0970-2067
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Container-title:Biomedicine
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language:
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Short-container-title:Biomedicine
Author:
Lobo Lancelot,Rohith M. James,Kumari N. Suchetha,Prasad H. L. Kishan
Abstract
Introduction: Gastric cancer (GC) is the fourth most prevailing cancer globally, attributing to more than 70% of cases in developing countries. Protein cancer biomarkers, such as CEA, CA- 125, AFP and PSA, are clinically helpful diagnostic tools, but they have low sensitivity and specificity for GC. Hence, it is essential to discover better markers for GC diagnosis. Interleukin-18 (IL-18) is the member of Interleukin-1 family. It is hypothesized to be a potent inhibitor of gastric acid secretion, leading to gastric atrophy and causing an increased risk of GC. This study was to evaluate the association between the serum IL-18 in GC.
Methodology: We included cases who underwent UGI Scopy and were proven to have GC histopathologically. The patients who presented to the out-patient who underwent UGI scopy and was found to have no growth were selected as controls. Twenty-eight cases and 84 control sample sizes were derived from nMaster V2. Blood samples from patients and controls were collected, and serum IL-18 levels were estimated using a solid-phase sandwich ELISA method.
Results: We found that the cut-off value of serum IL-18 was 85.59 pg/ml, had a sensitivity of 63.1% and specificity of 57.1%, with a positive predictive value of 81.5% and a negative predictive value of 34% in diagnosing GC. The study plotted the receiver operating characteristic curve against IL-18 for sensitivity and specificity. Statistically, we found through the Area Under the Curve (AUC) that the rise in serum IL-18 levels was a poor indicator of GC with a p-value of 0.078.
Conclusion: Statistically, a cut-off of 85.59pg/ml showed good sensitivity and specificity; however, the probability was insignificant, suggesting that IL-18 may not be of diagnostic importance. Studies with a larger sample size are required to further probe into the usefulness of estimating IL-18 in GC.
Publisher
Indian Association of Biomedical Scientists
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference21 articles.
1. Rahman, R., Asombang, A.W., Ibdah, J.A. Characteristics of gastric cancer in Asia. World J Gastroenterol. 2014 Apr 28;20(16):4483-4490. 2. Shikata, K., Kiyohara, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Shirota, T., et al., Prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study. Int J Cancer 119(1): 196-201. 3. Sung, N.Y., Choi, K.S., Park, E.C., Park, K., Lee, S.Y., Lee, A.K., et al., Smoking, alcohol and gastric cancer risk in Korean men: the National Health Insurance Corporation Study. Br J Cancer. 2007 Sep 3;97(5):700-704. 4. Chao, A., Thun, M.J., Connell, C.J., McCullough, M.L., Jacobs, E.J., Flanders, W.D., et al., Meat consumption and risk of colorectal cancer. JAMA. 2005 Jan 12;293(2):172-182. 5. Aird, I., Bentall, H.H., Roberts, J.A. A relationship between cancer of the stomach and the ABO blood groups. Br Med J. 1953 Apr 11;1(4814):799-801.
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