Regulation of lipid metabolism by 1,2,4-trioxolanes and betulin under hypoxia and immobilization stress in rats

Abstract

Introduction. Lipid metabolism disorders, caused by both excessive physical and psycho-emotional stress, and physical hypoxia, are important problems in the prevention and treatment of a number of diseases.The objective was to study the effect of 1,2,4-trioxolanes and betulin in fish oil on lipid and energy metabolism in an experiment on rats under hypoxia and immobilization stress (IS).Methods and materials. The studies were carried out using 75 male Wistar rats (intact and experimental animals) on a model of hypoxia and immobilization stress for 10 days. The treatment was carried out with the composition of betulin (0.1 %), 1,2,4-trioxolanes (10 %) in fish oil.Results. Under stress, regardless the type of stress, in groups without treatment, there was a significant disturbance in lipid metabolism, which was reflected in the following indicators: total cholesterol increases by 5–8 %, TG increase by 5 times, HDL increase by 10 %, VLDL and LDL increase by ~ 6 times. It was revealed that the composition of fish oil, botulin and 1,2,4-trioxolanes, previously obtained by ozonation of lipids, had a normalizing effect on the indexes of lipid and energy metabolism under hypoxia and IS in rats.Conclusions. 1,2,4-trioxolanes with betulin in fish oil may be useful for population groups with physical inactivity (students, office workers, elderly people, disabled people), as well as for athletes with excessive physical activity.