GLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitis
Shizuhide Nakayama1, Jun Nishio2, Mikiko Aoki3, Kaori Koga3, Kazuki Nabeshima4 and Takuaki Yamamoto1
1Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 2Section of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, 3Department of Pathology, Faculty of Medicine, Fukuoka University and 4Department of Pathology, Pathological Diagnosis Center, Fukuoka Tokushukai Hospital, Fukuoka, Japan
Corresponding Author: Dr. Shizuhide Nakayama, Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. e-mail: n.shizuhide@gmail.com
Summary. Myxofibrosarcoma (MFS) is a fibroblastic/myofibroblastic neoplasm with a variably myxoid stroma. Histologically, MFS shows a wide spectrum of cellularity, pleomorphism and proliferative activity. Because of its variable morphology and lack of discriminatory markers, MFS can be difficult to distinguish from some benign soft-tissue tumors, especially nodular fasciitis (NF). Glucose transporter 1 (GLUT-1) is expressed in a variety of malignant mesenchymal tumors. In the current study, we evaluated GLUT-1 expression to determine its value in distinguishing MFS from NF. Tissue specimens from 14 MFS cases and 16 NF cases were sectioned and stained for GLUT-1 using immunohistochemistry. The percentage of GLUT-1-positive cells was scored as follows: 0 (no staining), 1+ (1%–19%), 2+ (20%–50%) and 3+ (>50%). Samples with a score of 1+ were defined as GLUT1-expressing samples. GLUT-1 expression was seen in all 14 MFS cases, whereas only 6 NF cases (37.5%) were positive for GLUT-1 and were scored 1+. Notably, 2–3+ GLUT-1 expression was found in 86% of MFS cases and 0% of NF cases. Our results indicate that GLUT-1 is a highly sensitive immunohistochemical marker for MFS and may be useful for the differential diagnosis of MFS and NF. Histol Histopathol 38, 47-51 (2023)
Key words: GLUT-1, Myxofibrosarcoma, Nodular fasciitis, Immunohistochemistry
DOI: 10.14670/HH-18-490
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©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
