Claudin-1 role in colon cancer: An update and a review

Abderrahman Ouban

Alfaisal University and King Faisal Specialist Hospital and Research Centre (KFSH RC), Riyadh, Kingdom of Saudi Arabia

Offprint requests to: Abderrahman Ouban, MD, MPH, King Faisal Specialist Hospital, and Research Centre, Riyadh, Kingdom of Saudi Arabia. e-mail: aouban@alfaisal.edu

Summary. Tight junction proteins are essential for sealing the cellular sheets and controlling para-cellular ion flux. Our understanding of the role that tight junction proteins, particularly claudins, play in cellular functions and pathologic conditions is continuously expanding. Particularly, the role of claudin-1 in oncogenesis in multiple locations in the human body is coming to light. This review will shed light on the role of claudin-1 in colon cancer. It will address the mechanisms through which claudin-1 becomes dysregulated in colon cancer. This will provide a platform to address results of claudin-1 expression in the third most common malignant tumour worldwide. Furthermore, it will provide updates about possible use of this biomarker in the surveillance of difficult colon maladies, such as inflammatory bowel disease. The use of claudin-1 as a biomarker of diagnostic and prognostic values will provide Medicine with much needed ammunition in the fight against cancer and will bring about, with added refinements, a new chapter in the era of personalized medicine to tackle this disease and match its destructive course with equally powerful and specifically targeted therapies. Histol Histopathol 33, 1013-1019 (2018)

Key words: Colorectal cancer, Tight junction, Oncogenesis, Metastases, Claudin

DOI: 10.14670/HH-11-980