Role of insulin signaling and its associated
signaling in glomerulus for diabetic kidney disease
Akira Mima1 and Toshinori Yasuzawa1,2
1Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka and
2School of Human Cultures, University of Shiga Prefecture, Shiga, Japan
Corresponding Author: Akira Mima, M.D., Ph.D., Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka, 569-8686, Japan. e-mail: akira.mima@ompu.ac.jp
Summary. The number of patients with diabetic kidney disease (DKD) has been rising significantly over the last several decades and is one of the most frequent causes of chronic kidney disease (CKD) in the United States. Hyperglycemia accelerates development of DKD, a direct result of increased intracellular glucose availability. Two large clinical studies, the Diabetes Control and Complications Trial in type 1 diabetes and the United Kingdom Prospective Diabetes Study in type 2 diabetes showed that intensive glycemic control delayed the onset and the progression of DKD. On the other hand, it is reported that glycemic control alone is not sufficient to control DKD progression.
Recent data support that insulin signaling and its associated signaling contribute significantly to preserve glomerular function. However, little is known about the key regulators of insulin signaling in glomerular component cells. In this review, we summarize the novel knowledge regarding the reno-protective effects of insulin signaling or its associated signaling in glomerular constituent cells on DKD. Histol Histopathol 38, 487-492 (2023)
Key words: Diabetic kidney disease (DKD), Insulin signaling, Insulin receptor substrate 1 (IRS1), Vascular endothelial growth factor (VEGF), Pyruvate kinase M2 (PKM2)
DOI: 10.14670/HH-18-543
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ŠThe Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License. |