Vitiligo and anti-tissue Transglutaminase of celiac disease in Al- Nasiriyah city, Iraq

Abstract

       Vitiligo is acquired pigmentation disorder characterized by sharply defined white spots of irregular shape and variable dimensions, increasing in volume and number over time. The causes of vitiligo are still unknown. But it involve some theories like autoimmunity, this study was aimed to detection the relationship between the vitiligo and celiac disease by investigating the presence of celiac tissue transglutaminase IgA(tTGA) autoantibody in patients of vitiligo by using ELISA technique  . The study was conducted on 100 patients with vitiligo and 100 healthy individual  as control , the mean age of vitiligo patient was 19.4 year and control was 26.3 year .The results of study were showed  , twenty six of cases have family history of vitiligo , 53 of cases have family history of other autoimmune disorders, as well as  4 of cases have positive family history of vitiligo with diabetes and thyroid disorders. Tissue transglutaminase IgA antibody test was showed ,12 out of 100 of vitiligo cases  were  registered Seropositivity result to tTGA antibody, while 4 out of 100 of control were Seropositive to this antibody ,other cases and control were negative for IgA antibody.