Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry

Author:

Maeda Yukari1,Koshizaka Masaya1,Shoji Mayumi1,Kaneko Hiyori1,Kato Hisaya1,Maezawa Yoshiro1,Kawashima Junji2,Yoshinaga Kayo2,Ishikawa Mai3,Sekiguchi Akiko3,Motegi Sei-Ichiro3,Nakagami Hironori4,Yamada Yoshihiko5,Tsukamoto Shinji6,Taniguchi Akira6,Sugimoto Ken7,Takami Yoichi8,Shoda Yukiko9,Hashimoto Kunihiko10,Yoshimura Toru11,Kogure Asako12,Suzuki Daisuke12,Okubo Naoki13,Yoshida Takashi14,Watanabe Kazuhisa15,Kuzuya Masafumi16,Takemoto Minoru17,Oshima Junko118,Yokote Koutaro1

Affiliation:

1. Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan

2. Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

3. Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan

4. Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

5. Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Atami Hospital, International University of Health and Welfare, Atami, Japan

6. Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan

7. General Geriatric Medicine, Kawasaki Medical School, Okayama, Japan

8. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

9. Department of Dermatology, Sumitomo Hospital, Osaka, Japan

10. Department of Endocrinology and Metabolic Medicine, Nippon Life Hospital, Osaka, Japan

11. Diabetes and Endocrinology, Saga-Ken Medical Centre Koseikan, Saga, Japan

12. Department of Dermatology, Showa General Hospital, Tokyo, Japan

13. Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

14. Department of Orthopaedic Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan

15. Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

16. Geriatric Medicine, Meitetsu Hospital, Nagoya, Japan

17. Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, International University of Health and Welfare, Narita, Japan

18. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

Reference68 articles.

1. Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population.;Thomas;Hum Genet,1997

2. Prevalence of Werner's syndrome heterozygotes in Japan.;Furuichi;Lancet,1999

3. WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.;Baris;Hum Mutat,2017

4. Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome.;Yokote;J Am Geriatr Soc,2017

5. Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome.;Matsuura;Biosci Trends,2008

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