MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1

Author:

Sun Xin1,Jiang Shiwen2,Liu Jian1,Wang Huangzhen1,Zhang Yiwen1,Tang Shou-Ching34,Wang Jichang5,Du Ning1,Xu Chongwen1,Wang Chenguang6,Qin Sida1,Zhang Jia1,Liu Dapeng1,Zhang Yunfeng1,Li Xiaojun1,Wang Jiansheng1,Dong Jun7,Wang Xin8,Xu Shaohua9,Tao Zhen10,Xu Fei11,Zhou Jie12,Wang Tao13,Ren Hong1

Affiliation:

1. Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China

2. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China

3. Breast Cancer Program and Interdisciplinary Translational Research Team, Georgia Regents University Cancer Center, Augusta, Georgia, 30912, United States

4. Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China

5. Neurosurgery Department of the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China

6. Institute of Radiation Medicine, the Chinese Academy of Medical Sciences, Nankai District, Tianjing 300192, China

7. Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China

8. Department of Gastroenterology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China

9. Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China

10. Department of Radiation Oncology, Tianjin Cancer Institute and Hospital Affiliated to Tianjin Medical University, Tianjin, 300060, China

11. Department of Radiation Oncology, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China

12. Department of Breast Oncology, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, 510182, China

13. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China

Publisher

Impact Journals, LLC

Subject

Oncology

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