Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells

Author:

Dong Ling1,Lv Huijuan1,Li Wei1,Song Zheng1,Li Lanfang1,Zhou Shiyong1,Qiu Lihua1,Qian Zhengzi1,Liu Xianming1,Feng Lixia1,Meng Bin2,Fu Kai13,Wang Xi4,Pan-Hammarström Qiang15,Wang Ping6,Wang Xianhuo1,Zhang Huilai1

Affiliation:

1. Department of Lymphoma, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

2. Department of Pathology, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

3. Department of Pathology and Microbiology and Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

4. Department of Cellular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

5. Department of Laboratory Medicine, Clinical Immunology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden

6. Department of Radiotherapy, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Publisher

Impact Journals, LLC

Subject

Oncology

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