Abstract
Depression is one of the most severe mental disorders, and facing the challengeable lack of objective diagnosis, as well as early screening and predicting treatment responses. Consequently, developing sensitive, efficient, convenient, accurate, and real-time detection technology for depression markers earns more attention. Electrochemical immunosensor, as a promising method for analyzing disease markers, selectively binds the target antigen with antibodies (Abs), converting the biological signal of the antigen-antibody recognition reaction into an electrical signal related to the concentration of the target analyte. This method has thrived in recent years in areas such as point-of-care (POC) diagnosis. This article systematically reviews the construction of electrochemical immunosensors for the detection of biomarkers of depression over the past 6 years (2016–2022), including the classification of these sensors, commonly used electrode modification materials, and signal optimization strategies. Finally, the challenges and future development of electrochemical immunosensors in clinical applications are prospected.
Funder
Supported by the Fundamental Research Funds for the Central Universities
the major science and technology project of Gansu Province
the National Natural Science Foundation of China
Government Guiding Local Science and Technology Development Fund Project
the Talent Innovation and Entrepreneurship Project of Lanzhou
the Gansu Province People's Livelihood Science and Technology Special Project-Rural Revitalization Special Project
the Central the Special Project of Science and Technology Commissioner of Gansu Province
Publisher
The Electrochemical Society
Subject
Materials Chemistry,Electrochemistry,Surfaces, Coatings and Films,Condensed Matter Physics,Renewable Energy, Sustainability and the Environment,Electronic, Optical and Magnetic Materials