Discussion on the Effect of Small Qinglong Decoction on Airway Remodeling in Asthma, Based on TGF-β1/Smads Signaling Pathway and MMP-9

Abstract

Airway remodeling has always existed in the process of bronchial asthma, Airway remodeling is a key pathological change in the development of bronchial asthma, It is one of the important factors of recurrent and refractory. In this paper, TGF-β1 / smads signaling pathway and MMP-9 were used to explore the effect of Small qinglong decoction on airway remodeling in asthma. TGF-β1 / smads signaling pathway, it is the main regulatory factor leading to airway remodeling in bronchial asthma, by activating the Smad2 / 3 pathway, stimulate the proliferation of fibroblasts into myofibroblasts, resynthesized collagen and fibronectin accumulate and deposit in the extracellular matrix (ECM), eventually leading to airway remodeling. Matrix metalloproteinase-9 (MMP-9) is a key enzyme in ECM remodeling, it can degrade various protein components of ECM, involved in the occurrence of airway remodeling. TGF-β1 can induce neutrophils to release a large amount of MMP-9, exacerbating airway remodeling by promoting the synthesis of ECM. Small qinglong decoction is widely used in bronchial asthma clinical treatment. It can inhibit the expression of TGF-β1/smads signaling pathway, reduces MMP-9 secretion, reduces inflammatory reaction, then affect the airway remodeling of bronchial asthma.