Considering sex as a biological variable in preclinical research

Author:

Miller Leah R.1,Marks Cheryl2,Becker Jill B.3,Hurn Patricia D.4,Chen Wei‐Jung5,Woodruff Teresa6,McCarthy Margaret M.7,Sohrabji Farida5,Schiebinger Londa8,Wetherington Cora Lee9,Makris Susan10,Arnold Arthur P.1112,Einstein Gillian131415,Miller Virginia M.1617,Sandberg Kathryn1819,Maier Susan1,Cornelison Terri L.1,Clayton Janine A.1

Affiliation:

1. Office of Research on Women's Health Bethesda Maryland USA

2. Division of Cancer BiologyNational Cancer Institute Bethesda Maryland USA

3. Molecular and Behavioral Neuroscience Institute Ann Arbor Michigan USA

4. School of NursingUniversity of Michigan Ann Arbor Michigan USA

5. Department of Neuroscience and Experimental TherapeuticsTexas A&M Health Science Center Bryan Texas USA

6. Women's Health Research InstituteNorthwestern University Chicago Illinois USA

7. Department of PharmacologyUniversity of Maryland Baltimore Maryland USA

8. History of ScienceStanford University Stanford California USA

9. National Institute on Drug AbuseNational Institutes of Health Bethesda Maryland USA

10. Office of Research and DevelopmentNational Center for Environmental Assessment, U.S. Environmental Protection Agency Washington D.C. USA

11. Department of Integrative Biology and Physiology California USA

12. Laboratory of Neuroendocrinology of the Brain Research InstituteUniversity of California, Los Angeles, Los Angeles California USA

13. Department of Psychology Toronto Ontario Canada

14. The Dalla Lana School of Public HealthUniversity of Toronto Toronto Ontario Canada

15. Women's College Research Institute Toronto Ontario Canada

16. Department of Surgery and Physiology Rochester Minnesota USA

17. Department of Biomedical EngineeringMayo Clinic Rochester Minnesota USA

18. Department of Medicine Washington D.C. USA

19. Center for the Study of Sex Differences in HealthAging and Disease, Georgetown University Medical Center Washington D.C. USA

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference22 articles.

1. A call for transparent reporting to optimize the predictive value of preclinical research

2. Males still dominate animal studies;Zucker I.;Nature,2010

3. Policy: NIH plans to enhance reproducibility

4. National Institutes of Health. (2015).Consideration of sex as a biological variable in NIH‐funded research. Accessed June 30 2016 at:http://grants.nih.gov/grants/guide/notice‐files/NOT‐OD‐15–102.html

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