Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier

Author:

Soldner Emma L. B.1,Hartz Anika M. S.23,Akanuma Shin-Ichi45,Pekcec Anton6,Doods Henri6,Kryscio Richard J.27,Hosoya Ken-Ichi5,Bauer Björn48

Affiliation:

1. Department of Pharmacy Practice and Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Duluth, Minnesota, USA;

2. Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA;

3. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA;

4. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA;

5. Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan;

6. Research Beyond Borders, Boehringer Ingelheim Pharma GmbH, Biberach an der Riss, Germany;

7. Department of Statistics, University of Kentucky, Lexington, Kentucky, USA;

8. Epilepsy Center, University of Kentucky, Lexington, Kentucky, USA

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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