Affiliation:
1. Department of Neurology University of Michigan Ann Arbor Michigan USA
2. Division of Nephrology, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA
3. Department of Molecular and Integrative Physiology University of Michigan Ann Arbor Michigan USA
4. Department of Internal Medicine University of Michigan Ann Arbor Michigan USA
5. Department of Medicine University of Arizona Tucson Arizona USA
Abstract
AbstractPatients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN), which decrease quality of life and increase mortality. Unfortunately, treatment options for DKD and DPN are limited. Lifestyle interventions, such as changes to diet, have been proposed as non‐pharmacological treatment options for preventing or improving DKD and DPN. However, there are no reported studies simultaneously evaluating the therapeutic efficacy of varying dietary interventions in a type 2 diabetes mouse model of both DKD and DPN. Therefore, we compared the efficacy of a 12‐week regimen of three dietary interventions, low carbohydrate, caloric restriction, and alternate day fasting, for preventing complications in a db/db type 2 diabetes mouse model by performing metabolic, DKD, and DPN phenotyping. All three dietary interventions promoted weight loss, ameliorated glycemic status, and improved DKD, but did not impact percent fat mass and DPN. Multiple regression analysis identified a negative correlation between fat mass and motor nerve conduction velocity. Collectively, our data indicate that these three dietary interventions improved weight and glycemic status and alleviated DKD but not DPN. Moreover, diets that decrease fat mass may be a promising non‐pharmacological approach to improve DPN in type 2 diabetes given the negative correlation between fat mass and motor nerve conduction velocity.
Funder
A. Alfred Taubman Medical Research Institute
National Institute of Diabetes and Digestive and Kidney Diseases
Novo Nordisk Foundation Center for Basic Metabolic Research
Sydney Medical School Foundation
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology