Affiliation:
1. Department of Cell Biology, School of Life Sciences Central South University Changsha China
2. Department of Biomedical Informatics, School of Life Sciences Central South University Changsha China
Abstract
AbstractZinc finger proteins (ZNFs) are the largest family of transcriptional factors in mammalian cells. Recently, their role in the development, progression, and metastasis of malignant tumors via regulating gene transcription and translation processes has become evident. Besides, their possible involvement in drug resistance has also been found, indicating that ZNFs have the potential to become new biological markers and therapeutic targets. In this review, we summarize the oncogenic and suppressive roles of various ZNFs in malignant tumors, including lung, breast, liver, gastric, colorectal, pancreatic, and other cancers, highlighting their role as prognostic markers, and hopefully provide new ideas for the treatment of malignant tumors in the future.
Funder
Health Commission of Hunan Province
Natural Science Foundation of Hunan Province
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Cited by
2 articles.
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