Predicting susceptibility to SARS‐CoV‐2 infection based on structural differences in ACE2 across species

Author:

Alexander Matthew R.12,Schoeder Clara T.34,Brown Jacquelyn A.56,Smart Charles D.7,Moth Chris38,Wikswo John P.5679,Capra John A.38,Meiler Jens34910,Chen Wenbiao7,Madhur Meena S.12711

Affiliation:

1. Department of Medicine Division of Cardiovascular Medicine Vanderbilt University Medical Center (VUMC) Nashville TN USA

2. Department of Medicine Division of Clinical Pharmacology Vanderbilt University Medical Center Nashville TN USA

3. Center for Structural Biology Vanderbilt University Nashville TN USA

4. Department of Chemistry Vanderbilt University Nashville TN USA

5. Department of Physics and Astronomy Vanderbilt University Nashville TN USA

6. Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University Nashville TN USA

7. Department of Molecular Physiology and Biophysics Vanderbilt University Nashville TN USA

8. Department of Biological Sciences Vanderbilt University Nashville TN USA

9. Department of Biomedical Engineering Vanderbilt University Nashville TN USA

10. Institute for Drug Discovery Leipzig University Medical School Leipzig Germany

11. Vanderbilt Institute for Infection, Immunology, and Inflammation Nashville TN USA

Funder

National Institutes of Health

American Heart Association

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference61 articles.

1. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review

2. Probable pangolin origin of SARS‐CoV‐2 associated with the COVID‐19 outbreak;Zhang T;CB,2020

3. APHISpress@usda.gov. (April 6 2020).USDA Statement on the Confirmation of COVID‐19 in a Tiger in New York. United States Department of Agriculture Animal and Plant Health Inspection Service.https://www.aphis.usda.gov/aphis/newsroom/news/sa_by_date/sa‐2020/ny‐zoo‐covid‐19

4. APHISpress@usda.gov. (August 13 2020).Confirmed cases of SARS‐CoV‐2 in animals in the United States. United States Department of Agriculture Animal and Plant Health Inspection Service.https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/SA_One_Health/sars‐cov‐2‐animals‐us

5. Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

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