An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols-Reference-Cited by-同舟云学术

An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols

Published:2025-05-15 Issue:1 Volume:23 Page:43-48
ISSN:2518-1548
Container-title:Journal of Organic and Pharmaceutical Chemistry
language:
Short-container-title:J. Org. Pharm. Chem.

Author:

Borysov Oleksandr V.¹^ORCID,Bohdan Dmytro P.²

Affiliation:

1. Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd.

2. Institute of Organic Chemistry of the National Academy of Sciences of Ukraine

Abstract

A practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thiols with F, Cl, Br, CH3, OCH3 substituents at various positions of the pyridine ring. The procedure presented gives high yields of the target products with a purity of 95% and is suitable for synthesis in tens of grams.

Publisher

National University of Pharmacy

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