Study the immunostimulatory properties of a solution for injection comprising natural powdered honey in laboratory animals-Reference-Cited by-同舟云学术

Study the immunostimulatory properties of a solution for injection comprising natural powdered honey in laboratory animals

Published:2024-06-27 Issue:2 Volume:10 Page:7-12
ISSN:2411-0388
Container-title:Journal for Veterinary Medicine, Biotechnology and Biosafety
language:en
Short-container-title:J. Vet. Med. Biotechnol. Biosafety

Author:

Yemelianov A. V.¹^ORCID,Koshova O. Yu.²^ORCID,Sumakova N. V.¹^ORCID,Paliy A. P.¹^ORCID

Affiliation:

1. National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine

2. National University of Pharmacy, Kharkiv, Ukraine

Abstract

The article presents the results of pharmacological studies of a new domestic drug ‘Apimel’ in the form of a solution for injection based on natural powdered honey as an active ingredient. The effect of the solution for injections with natural powdered honey on the severity of the immune response in rats and mice with normal immune status was studied, and the immunostimulating properties of the drug ‘Apimel’ in mice with immunodeficiency were studied. It was found that the most pronounced immunostimulatory properties of the drug were observed in doses of 50 and 250 mg of natural powdered honey/kg body weight. The study of the effect of the drug on the development of a slow-type hypersensitivity reaction in mice revealed the anti-inflammatory properties of the drug at doses of 25 and 150 mg of natural powdered honey per kilogram of body weight. In the course of studying the immunostimulating properties of the investigated drug in mice with immunodeficiency, it was found that the solution for injection at a dose of 50 mg of natural powdered honey/kg body weight restored the processes of antibody formation at the level of the comparison drug, and significantly exceeded it in terms of the expression of phagocytic activity of neutrophils

Publisher

Kharkiv Entomological Society

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